Active Ingredient: Doxycycline
No patients returned with PCR-confirmed R.
Conclusion In Lao adults, azithromycin is inferior to doxycycline as oral therapy for uncomplicated murine typhus. For doxycycline, 3- and 7-day regimens have similar efficacy.
Azithromycin use in murine typhus should be reconsidered. Investigation of genomic and phenotypic markers of R.
Keywords: murine typhus, Rickettsia typhi, Laos, doxycycline, azithromycin Murine typhus, caused by Rickettsia typhi, is a neglected global flea-borne disease with sparse worldwide data on epidemiology and no randomized clinical trials to guide therapy.
Although most commonly a febrile illness with few localizing signs, it also causes severe disease, such as meningoencephalitis and pneumonitis.
The diagnosis of R. Tetracyclines are the mainstays of treatment, but there is minimal evidence on optimal duration or how to treat in pregnancy, childhood, or severe disease.
A review of Cretan patients with murine typhus suggested that doxycycline was associated with a shorter fever clearance time FCT than chloramphenicol or fluoroquinolones. The clinical efficacy of fluoroquinolones is in doubt, with equivocal evidence for azithromycin.
Note that this reiew was selected because of the useless but sometimes common practice of using topical antibiotics on clean wounds.
J Emerg Med. Note that this sensitivity pattern is similar to that of many other reports for the past 4 years. Empiric outpatient therapy with trimethoprim-sulfamethoxazole, cephalexin, or clindamycin for cellulitis.
Practice guidelines for the diagnosis and management of skin and soft tissue infections: update by the Infectious Diseases Society of America.