Active Ingredient: Doxycycline
Recent deployments in Mali and Central African Republic showed high incidence rates, with a significant risk of contracting malaria for the soldiers.
The attack rates were estimated at 7.
These failures of prophylaxis with doxycycline are mainly associated with inadequate dosing or poor compliance. Classification Tetracyclines are synthetic antibiotics derived from a cycline that is naturally produced by bacteria from the genus Streptomyces.
Tetracycline consists of three groups, based on pharmacological differences: the long-acting group, which includes doxycycline and minocycline, are the most active against Plasmodium in vitro.About doxycycline Doxycycline is an antibiotic STIs, as well as a lot. It's used to treat infections such as chest infections, skin infections, rosacea, dental infections and sexually transmitted infections of other rare infections.
The antibiotic action, common to all tetracycline, is bacteriostatic and inhibits bacterial protein synthesis; their spectrum of activity is large. Pharmacological properties The pharmacokinetics properties of doxycycline have been investigated in numerous studies with healthy volunteers.
Only one study of the pharmacokinetics of doxycycline was conducted during infections. It involved a case of uncomplicated malaria in combination with quinine or artesunate. Side effects and warnings against doxycycline Tetracyclines are well known for their use in treating bacterial infections, and their adverse effects have been well documented.
At the usual doses prescribed for malaria chemoprophylaxis, the published data are limited, and the reported adverse events vary widely.
Comparative studies of the tolerance of doxycycline have been contradictory. Several retrospective studies of military teams have reported increased digestive and skin disorders and headaches with chemoprophylaxis.
Thus, it is difficult to attribute an adverse event to cyclines only. In 1996 in sub-Saharan Africa, the French Army Health Service conducted an efficacy study of doxycycline hyclate salt versus chloroquine-proguanil. Doxycycline hyclate was more efficacious than chloroquine-proguanil.
The gastrointestinal side effects e. According to the French Drug Agency recommendations, doxycycline hyclate has been replaced by doxycycline monohydrate, a less acidic salt pH 6 with the same bioavailability.
Gastrointestinal side effects, mouth ulcers, and sun sensitization occurred less frequently in the doxycycline monohydrate group than in the chloroquine-proguanil group.