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The denial letter will outline directions on how to appeal the decision. It has been suggested that Leptospira interrogans serovar icterohaemorrhagiae was introduced to western Europe in the 18 th century by westward extension of the range of of Rattus norvegicus from Eurasia 24.
The etiology of leptospirosis was demonstrated independently in 1915 in Japan and Germany 207. Uhlenhuth and Fromme 588 and Hubener and Reiter 289 detected spirochetes in the blood of guinea pigs inoculated with the blood of infected soldiers.
Unfortunately, these two groups became so embroiled in arguments over priority that they overlooked the first publications in English 296 and German of papers by Inada's group, whose initial publications predated their own by 8 months 207.
Confirmation of the occurrence of leptospirosis on both sides of the Western Front was obtained rapidly after the publication in Europe of Inada's work 131, 145, 543.
Given the initial controversy over nomenclature, it is ironic that the organism had first been described almost 10 years before 542.
Stimson demonstrated by silver staining the presence of clumps of spirochetes in the kidney tubules of a patient who reportedly died of yellow fever.
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