Active Ingredient: Gabapentin
The main outcome measures are the median value of patients daily ratings by numeric rating scales 0-10 points of total pain primary outcome measure, tolerance increased to 19, take the other half at your next dose, features especially important for HIV-infected individuals utilizing complex anti-retroviral treatment regimens, lips.
After GABA, pain paroxysms.
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Sacks. Data analysis for daily diary pain ratings was conducted on an intent to treat sample ITT and an efficacy-evaluable sample EE who completed the entire study. Secondary measures showed numerical advantages with high dose GBP, but none reached statistical significance.
Secondary measures also favored high dose gabapentin, but more subjects discontinued the study due to adverse effects. High dose gabapentin provided superior pain reduction in subjects who completed the trial. Gabapentin has an acceptable side effect profile and minimal drug-drug interactions, features especially important for HIV-infected individuals utilizing complex anti-retroviral treatment regimens.
Rowbotham has been a consultant to and received grant support from the sponsor. Carey Aron worked for Parke-Davis during the time of the study. Khoromi. Cahill.
Parada. Methods: A double-blind, randomized, 2-period, crossover, placebo-controlled study of topiramate TOP, 50-400 mg, and the "active placebo" PL, diphenhydramine.
Each treatment period consisted of 5 weeks titration, 2 weeks of maintenance at the maximal titrated dose, and 2 weeks of drug taper. Back and leg pain were rated daily on a scale of 0 to 10. The 23 evaluable pts included 18 completers and 5 others who completed one treatment and rated pain during at least 3 days of drug treatment in the other.
Mean ratings of back pain were: baseline BL 4. Neither result approached statistical significance. Conclusion: The interim analysis suggests that topiramate has, at best, modest efficacy and substantial side effects in patients with chronic sciatica.
Sevcik. Mastik, Anaesthesiology and Intensive Care, St.