Active Ingredient: Gabapentin
X was given a breathalyzer test and easily passed it. Potential drug—drug interactions with the 3 D regimen were identified by applying pharmacokinetic study data to known routes of metabolism and disposition of more than 200 prescription and over-the-counter drugs.
The majority of concomitant medications assessed are compatible with 3 D therapy.
One such investigational combination includes ombitasvir, paritaprevir identified as a lead compound by AbbVie, Inc. This potent three-class combination approach has achieved high rates of sustained virologic response in a broad range of patients, including those with cirrhosis or those who have undergone liver transplant.
The antiviral activity of paritaprevir is boosted by its co-formulation with a low dose of ritonavir i. Ritonavir is a strong inhibitor of cytochrome P 450 CYP 3 A 4, a major enzyme involved in the metabolism of paritaprevir.
No graft rejection events occurred during the study.
The safety profile of the 3 D regimen was similar in patients with cirrhosis or who were post-transplant to that of the overall population and no significant associations were found between ombitasvir, dasabuvir, and ritonavir exposures and AEs or laboratory abnormalities.
Exposure-safety analyses showed that increases in paritaprevir exposure of up to 2-fold are not predicted to meaningfully increase AEs or laboratory abnormalities of Grade 3 or greater.
Because of these exposure changes, 3 D therapy is not recommended in patients with moderate hepatic impairment.
Therefore, 3 D therapy is contraindicated in patients with severe hepatic impairment. As new therapeutic options for treating HCV become available, it will be important to assess their abilities to interact with established medications, particularly those drugs or drug classes that are commonplace among patients with HCV infection.
In clinical practice, non-HCV medications that have the potential for interactions with HCV treatments are frequently prescribed to patients with chronic HCV infection.
Pharmacokinetic studies are the ideal method by which to evaluate the DDI potential of the 3 D regimen; however, such an undertaking is not feasible given the number of prescription and over-the-counter medications available and their various permutations.
With results from key DDI studies, data can then be extrapolated to other medications based on what is known about drug metabolism.
To provide clear guidance regarding the clinical use of the 3 D regimen and facilitate prescription decisions, in this report, we have gathered information on the metabolism and disposition of more than 200 commonly used drugs.
These data, together with DDI studies involving the 3 D regimen, were used to develop recommendations for DDI evaluation and management.
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