Active Ingredient: Gabapentin
Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal trial.
Physical functioning, quality of life, and emotional functioning also revealed no differences.
Small, nonsignificant changes occurred in opioid medication use. The most frequent device-related adverse events were transient postimplant lumbar puncture headache, pain, and nausea. The most frequent gabapentin-related adverse events were nausea, somnolence, headache, dizziness, fatigue, and peripheral edema.
Conclusion:: Twenty-two days of intrathecal gabapentin did not demonstrate statistically significant or clinically meaningful analgesic effects. The study sponsor has no current plans for further studies.
Drug-related adverse events were similar to those for oral gabapentin. Most device-related adverse events resulted from the implant surgery or anesthesia.
What We Already Know about This Topic Oral gabapentin is widely used to treat neuropathic and sometimes other forms of chronic pain Gabapentin has a presumed spinal site of action when used for chronic pain What This Article Tells Us That Is New In a prospective, blinded, placebo-controlled trial conducted on a heterogeneous group of patients with chronic pain, no analgesic effects were identified during 22 days of intrathecal gabapentin infusion PAIN, an unpleasant experience associated with actual or potential tissue damage, or described in terms of such damage, is always subjective.
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