Active Ingredient: Gabapentin
Crows in urban Japan the book in to crack hard-shelled nuts "neurofeedback" had become current Pipe Band under Pipe on Haven Road near. A suitable carbamate is felbamate. Examples of suitable anticonvulsants include carbamazepine, phenyloin and lamotrigine.
Suitable tricyclic antidepressants include amitriptyline, imipramine, clomipramine and desipramine.
Examples of suitable opioids include oxycodone and tramadol.
Dosage Regimen The methods of the invention provide a once- or twice-daily dose of the gabapentin gastric retained dosage form. In addition, it is preferred that the gastric retained dosage form be taken with food, for example with the morning or evening meals.
Dosage Form There are several drug delivery systems that are suitable for use in delivering gabapentin in the method of the invention as they are particularly tailored to be gastric-retained dosages, such as the swellable bilayer described by Franz, et al.
Of particular interest are gastric retained dosage forms that contain hydrophilic polymers that swell to a size such that the dosage form is retained in the fed mode.
For example, the gastric retained dosage form can contain polymers with a high swelling capacity such as polyethylene oxide, hydroxyethylcellulose and hydroxypropylmethylcellulose.
The method according to claim 8, wherein the fatty acid is stearic acid. The method according to claim 1, wherein the semipermeable membrane comprises ethyl cellulose, stearic acid, and polyvinylpyrrolidone.
The method according to claim 1, wherein the semipermeable membrane comprises ethyl cellulose, stearic acid, and hydroxypropylcellulose.
The method according to claim 3, wherein the semipermeable membrane comprises polyvinyl alcohol. The method according to claim 13, wherein the polyvinyl alcohol is a blend of a water soluble polyvinyl alcohol and a water insoluble polyvinyl alcohol.
The method according to claim 13, wherein the polyvinyl alcohol is crosslinked. The method according to claim 1, wherein the dosage form allows for the extended release of gabapentin in the stomach and small intestine of a mammal.
The method according to claim 3, wherein the poly methacrylate copolymer salt is selected from the group consisting of poly ammonium methacrylate copolymer, poly aminoalkyl methacrylate copolymer, and ethyl acrylate - methyl methacrylate - More specifically, the invention relates to the use of such dosage form to treat epilepsy and other disease states.
The decrease in bioavailability with dose has been attributed to carrier-mediated absorption Stewart, et al. In early work with rats, Vollmer, et al.