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The inhibition of DNA gyrase by BMS- and its analogues was also comparable to ciprofloxacin, levofloxacin and moxifloxacin.
Inhibition of S. The selectivities between bacterial and human topoisomerases of BMS-, BMS- analogues and quinolone comparators were determined by monitoring their inhibition of relaxation activity of recombinant hTopo II Table II.
The remainder of the compounds, including BMS-, had no inhibition at the highest soluble concentration tested.
Similar cytotoxicity results were observed for all quinolones when tested against the HeLa cells. Discussion In vitro testing demonstrated that BMS- has excellent activity against resistant strains of bacteria with multiple topoisomerase mutations and bacterial enzymatic targets.
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