Active Ingredient: Norfloxacin
Bramhill. Cross. Donachie. Dryselius.
Galloway. Geller. Gerdes.
While several clinical trials in the past had compared the clinical efficacy of these agents with another antibiotic such as FQs in patients with APN, none of the trials assessed the optimal duration of treatment regimens using non-FQ antibiotics other than co-trimoxazole; trials on hospitalized APN patients are particularly lacking.
Currently, the recommended treatment duration for non-FQ antibiotics is still 10—14 days, and hence the hospital stay is prolonged in the absence of suitable oral options and outpatient parenteral antibiotic treatment OPAT services.If you are under 18 years taking norfloxacin it is important that your doctor knows: If you are.
Notwithstanding, most APN patients treated with such antibiotics show clinical resolution within the first week of treatment, making clinicians contemplate whether these antibiotics could be stopped by the end of first week, without entailing an unduly high risk of retreatment for recurrent infection.
We therefore conducted a randomized controlled trial to test the hypothesis that, contingent upon clinical improvement, the effective non-FQ antibiotic regimen could be safely stopped at Day 7 while the risk of retreatment remains clinically acceptable in patients with APN requiring hospitalization.
Materials and methods We conducted a two-arm, parallel group, open-label, pragmatic randomized controlled trial with a non-inferiority design. Patients admitted with a provisional diagnosis of APN were eligible for this trial.
We obtained informed written consent from all participants. Journal ofAnimal Mise -935. Park. Therefore, as well as urinary and complementary medicines.