Active Ingredient: Norfloxacin
If the diarrhoea is severe or continues to be a problem, speak with your pharmacist or doctor for advice Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know Feeling dizzy Do not drive and do not use tools or machines until you feel well again Rash If this is severe, let your doctor know Important: there are also a number of less common but more serious side-effects which have been associated with norfloxacin.
Speak with your doctor as soon as possible if you experience the following: An allergic-type reaction, such as swelling around your face or mouth, a skin rash, or any difficulty breathing. Pain or swelling in your joints.
Problems with your vision or with your eyes. How to store norfloxacin Keep all medicines out of the reach and sight of children. Store in a cool, dry place, away from direct heat and light. Important information about all medicines Never take more than the prescribed dose.
If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital.
This medicine is for you.
Never give it to other people even if their condition appears to be the same as yours. Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the metabolic clearance of theophylline.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine.
This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0.
Patients given these more definitively phototoxic fluoroquinolones should be cautioned to avoid exposure to sunlight.
Glucose Metabolism Some quinolones have been shown in animal studies to increase insulin release from pancreatic islet cells 151. Reports of altered glucose metabolism with gatifloxacin led to its removal from the market; however, other quinolones have been infrequently associated with this complication 79.
In many reports, patients experiencing hypoglycemia had diabetes mellitus and were also being treated with a hypoglycemic medication. Cardiovascular Toxicity A great deal of attention has been directed to cardiovascular toxicity induced by some quinolones.
Several quinolones have been linked to QT prolongation and arrhythmias including torsades de pointes.
Extensive ECG testing was conducted during the development of moxifloxacin. Although individual quinolones alter cardiac action potential to varying degrees, cardiovascular toxicity appears to be a class effect.
Case reports and clinical studies show that moxifloxacin carries the greatest risk of QT prolongation from all available quinolones in clinical practice while ciprofloxacin appears to be associated with the lowest risk. As with the adverse events, there is no head-to-head comparative study, and the rank ordering is by inference on the basis of noncomparative reports and studies against the same or similar non-quinolone comparator antibiotics 122.
Some significant and potentially significant interactions are summarized below. Anticoagulants Studies on the interactions between quinolones and warfarin demonstrate that norfloxacin prolongs the elimination half-life of R -warfarin, while not affecting S -warfarin.
As such, drug elimination occurs to the greatest extent for trovafloxacin 41. Alternative investigators reported the formation of moxifloxacin MICs between 0.
But excretion of these compounds occurs via both type secretion and glomerular filtration, these en interactions involving the fluoroquinolones appear to be tract specific rather than a unit effect.