Active Ingredient: Azithromycin
The aim of the present study was to test the in vivo efficacy of ampicillin and azithromycin alone and in combination against a multi-drug resistant strain of SP in an experimental murine pneumonia model!
Our results showed that the combinations tested were active in inhibiting C.
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Although results from in vitro studies are available, in vivo studies must be conducted to confirm the effectiveness of these combination therapy strategies against isolates resistant to commonly recommended regimens.
SP isolates that were previously examined in human experimental colonization studies also colonized in inbred adult mice, thereby demonstrating the relevance of an animal model of pneumococcal pneumonia.
The aim of the present study was to test the in vivo efficacy of ampicillin and azithromycin alone and in combination against a multi-drug resistant strain of SP in an experimental murine pneumonia model.
Now the question, whether a combination of ampicillin and azithromycin would be effective in treatment against an isolate of SP non-susceptible to penicillin and macrolide needs further investigation in vivo.
The clinical isolate of S. Brain heart infusion broth BHI HiMedia, Bombay, India was used as the medium for pneumococcal cultures prior to experiments with mouse.
The MIC was defined as the lowest concentration of antibiotic at which no turbidity was visible to the naked eye. For determining MBC.
The MBC was defined as the lowest concentration of antibiotic that killed 99. Modal values from three separate determinations were taken as the working values.
All animals were maintained and utilized in accordance with recommendations from the IAEC and were provided with food and water ad libitum. The advantage of intranasal inoculation is to mimic oropharyngeal aspiration, effectively infects upper and lower respiratory tract and is very simple.
To investigate the change in colony forming units CFU in the lungs and blood, animals were sacrificed under ether anesthesia, from 18 th — 24 th h post infection.
Blood was collected by cardiac puncture and their whole lungs were removed aseptically. The MIC was defined as the lowest concentration of antibiotic at which no turbidity was visible to the naked eye.
For determining MBC. The MBC was defined as the lowest concentration of antibiotic that killed 99. Modal values from three separate determinations were taken as the working values. The objective of this study was to compare the role of monotherapy and combination therapy with ampicillin AMP and azithromycin AZM in eradicating bacterial burden and down regulating lung inflammation in a murine experimental pneumococcal infection model.