Active Ingredient: Azithromycin
This study was designed, upon the instructions and approval of the Ministry of Health MoH, Pakistan, to compare the bioequivalence of an azithromycin capsule formulation manufactured locally in the Khyber Pakhtunkhwa province with that of a reference formulation from a multinational manufacturer.
Of the 68 brands of the azithromycin capsule formulations available in Pakistan, only 5 are manufactured in the Khyber Pakhtunkhwa province.
Thus, the test formulation was randomly selected from these 5 brands using a computer-based random number table after assigning them numbers from 1 to 5. Nanoparticles are more effective for drug delivery, especially for highly hydrophobic agents, and can increase their low water solubility and dissolution rate.
Materials and Method 2. Nanoparticles Preparation Antisolvent precipitation with syringe pump APSP and evaporator precipitation nanosuspension EPN methods were used for the preparation of cefixime and azithromycin nanoparticles.
In ASP method, saturated solutions of both cefixime and azithromycin were prepared in 50 mL of methanol and ethanol, respectively.
Three different ratio 1: 10, 1: 15, and 1: 20 volumes of saturated drug solutions were mixed with the solution of deionized water. In samples cefixime A and B the solvent to antisolvent ratios were 1: 10 and 1: 15, respectively, while in case of azithromycin samples F, and H the solvent to antisolvent ratios were 1: 10, 1: 15, and 1: 20, respectively.
After stirring the resulting mixtures were evaporated quickly using a rotary evaporator to obtain nanoparticles.
In the EPN process, like the ASP method we prepared saturated solutions of both cefixime and azithromycin in the same solvents using the same volume.
The solutions were quickly added to hexane antisolvent, resulting in the formation of nanosuspensions. The nanosuspensions were achieved by repaid evaporation of the solvent and antisolvent, with the help of vacuum pump using a rotary evaporator.
In cefixime samples C, and E the solvent to antisolvent ratios were 1: 10, 1: 15, and 1: 20, respectively, while in case of azithromycin samples I, and K the solvent to antisolvent ratios were 1: 10, 1: 15, and 1: 20, respectively.
The antibacterial spectra of the novel preparations were determined by agar well diffusion method.All male and female patients of the efficacy of oral azithromycin with oral doxycycline in the treatment of acne vulgaris in our population. This study was conducted to compare age 14-30 years having moderate acne vulgaris on face only were included in the study.
Dissolution Study USP standard dissolution apparatus having six vessels for dissolution was used to perform the dissolution study. Buy Cheap Generics Online.
The cramps are becoming worse, sore boobs getting better, soft stools everyday and discharge has stoped. I need some hope here?
Constipation increases your risk of abdominal cramping, bloating, and gas. Yes, we know, you already have a busy life and feel tired every day, so you really have to be careful about this particular symptom.
The hood shall overhang the front edge of the oven by 18". Very interesting how you described it as yogurt stuck in your throat.