Active Ingredient: Azithromycin
If the patient vomits within 1 hour of consumption an alternative antibiotic should be considered. Conclusion Extended-release azithromycin is the only FDA-approved single-dose antibiotic for the treatment of community acquired pneumonia and acute bacterial sinusitis.
This is an example of the potential of nanotechnology to improve on existing therapies.
The active agent, azithromycin, was not changed, but the new delivery system has maximized pharmacodynamic parameters while allowing for more convenient dosing of the drug.
This drug is especially attractive where compliance is an issue because it is ideally suited to observed therapy. It also ensures completion of the antibiotic course. This, coupled with high first-day intracellular concentrations when bacterial load is greatest, have the theoretical chance of reducing bacterial resistance.
However, these advantages must be weighed against the increase in gastrointestinal side-effects and added cost of extended-release azithromycin because the immediate-release formulation is now generic. Despite improved pharmacodynamic parameters, there is no evidence supporting its clinical efficacy over immediate-release azithromycin.
In future we look forward to the evolving role of nanotechnology in the pharmaceutical field as it both improves on previous therapy, such as with extended-release azithromycin, and also contributes to the development of novel treatments.
References Amsden G.
Pneumococcal macrolides resistance—myth or reality? J Antimicrob Chemother. Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community acquired pneumonia in adults.Abstract PURPOSE Azithromycin use has been other articles in PMC. This article has been cited by associated with increased risk of death.
Antimicrob Agents Chemother. Single-dose azithromycin microspheres vs clarithromycin extended release for the treatment of mild-to-moderate community-acquired pneumonia in adults.
Pharmacokinetics of azithromycin in lung tissue, bronchial washing, and plasma in patients given multiple oral doses of 500 and 1000 mg daily.
Pharmacol Res. Rationale for single and high dose treatment regimens with azithromycin. Pediatr Infect Dis J. Dilemma in trial design: do current study designs adequately evaluate antibiotic effectiveness in ABRS?
Shake the oral suspension liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
Skipping doses can increase your risk of infection that is resistant to medication.
Azithromycin will not treat a viral infection such as the flu or a common cold. Store at room temperature away from moisture and heat. Throw away any unused liquid medicine after 10 days.
What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.